ARID4B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[1][2]
Function
[edit | edit source]This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[2]
References
[edit | edit source]External links
[edit | edit source]- Human ARID4B genome location and ARID4B gene details page in the UCSC Genome Browser.
Further reading
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