ARHGAP8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.[1][2]
Function
[edit | edit source]This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[2]
References
[edit | edit source]External links
[edit | edit source]- Human ARHGAP8 genome location and ARHGAP8 gene details page in the UCSC Genome Browser.
Further reading
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