ARF3

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

Function

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns.

Interactions

ARF3 has been shown to interact with:

• ARFIP1,
• ARFIP2,
• GGA1,
• GGA3, and
• KIF23.

External links

• Human ARF3 genome location and ARF3 gene details page in the UCSC Genome Browser.