APOL2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.[1][2][3]
This gene is a member of the apolipoprotein L gene family and protein in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is mainly found in the cytosol, nucleoplasm and additionally, it is also seen in the Nuclear bodies.[4] The involvement of this gene may affect in the movement of lipids and binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.[3]
Amino acid sequence
[edit | edit source]MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD ELRKALNKLA SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR ALAEEVEQVH RGTTIANVVS NSVGTTSGIL TLLGLGLAPF TEGISFVLLD TGMGLGAAAA VAGITCSVVE LVNKLRARAQ ARNLDQSGTN VAKVMKEFVG GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA PPPHVIGRIS AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ[5][6]
Total amino acids: 337[5]
Interactions
[edit | edit source]APOL2 has been shown to interact with:
Splice variants
[edit | edit source]ApoL2 has 5 splice variants,[11]
- APOL2-001
This transcript has 6 exons, 12 domains and features are annotated, 263 variations are related this and maps to 35 oligo probes.
- APOL2-002
This transcript has 5 exons, 12 domains and features are annotated, 263 variations are related with this gene and maps to 37 oligo probes.
- APOL2-006
This transcript has 6 exons, is annotated with 3 domains and features, 62 variations are related with this gene and maps to 20 oligo probes.
- APOL2-008
This transcript has 6 exons, 12 domains and features are annotated, 331 variations are related with this gene and maps to 32 oligo probes.
- APOL2-009
This transcript has 5 exons, 4 domains and features are annotated, 104 variations are related with this gene and maps to 13 oligo probes.
Functions of the ApoL2
[edit | edit source]- Acute Inflammation Response [12][13]
- Cholesterol Metabolic Process[14]
- Lipid Metabolic Process[10]
- Maternal Process Involved in Female Pregnancy[15]
- Lipid binding[16]
- Signalling Receptor Binding[16]
- Aging [17]
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- Human APOL2 genome location and APOL2 gene details page in the UCSC Genome Browser.
- Human APOL3 genome location and APOL3 gene details page in the UCSC Genome Browser.
Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
 | This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |