APOBEC3C
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). DNA dC->dU-editing enzyme APOBEC-3C is a protein that in humans is encoded by the APOBEC3C gene.[1][2]
A3C belong to the A3 family of cytidine deaminases that act as restriction factors against diverse retroviruses. A3C was reported to inhibit simian immunodeficiency deficiency virus potently rather than HIV-1, in absence of viral infectivity factor, Vif.[3] Enhancing A3C's catalytic activity had only a marginal effect on HIV-1 replication (in absence of Vif), the counteractive viral mechanism is unclear.[4] A3C was also shown to inhibit other viruses.[5][6][7][8][9]
Function
[edit | edit source]This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. Conversely, A3 proteins enzymatically convert cytidine to uridine present in the single stranded DNA.[10][11][12][13][14] Two residues in loop 1 of A3C were demonstrated to determine its antiviral activity against HIV-1.[15]
Structure
[edit | edit source]The crystal structure of A3C suggests a putative HIV-1 vif binding region.[16][17] A3C was found to inhibit LINE-1 elements by directly interacting with ORF1p proteins, in a deaminase-independent manner.[18]
References
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Further reading
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External links
[edit | edit source]- Human APOBEC3C genome location and APOBEC3C gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q9NRW3 ( DNA dC->dU-editing enzyme APOBEC-3C) at the PDBe-KB.
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