API5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). The human gene API5 encodes the protein Apoptosis inhibitor 5.[1][2]
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction [3]
Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.
API5 functions in nuclear export of mRNA.[4]
References
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Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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