APBA1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.[1][2][3]
Function
[edit | edit source]The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.[3]
Interactions
[edit | edit source]APBA1 has been shown to interact with KCNJ12,[4][5] CCS,[6] CASK[7][8] and Amyloid precursor protein.[9][10]
References
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Further reading
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External links
[edit | edit source]- Human APBA1 genome location and APBA1 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q02410 (Amyloid-beta A4 precursor protein-binding family A member 1) at the PDBe-KB.
