ANAPC7
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[1] Multiple transcript variants encoding different isoforms have been found for this gene.
Function
[edit | edit source]This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[1]
Interactions
[edit | edit source]ANAPC7 has been shown to interact with ANAPC1,[2][3] ANAPC4,[2] CDC27[2][4] and CDC20.[2][5]
References
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External links
[edit | edit source]- Human ANAPC7 genome location and ANAPC7 gene details page in the UCSC Genome Browser.
Further reading
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