ADCY10
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Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.[1]
Function
[edit | edit source]The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.[2]
Clinical significance
[edit | edit source]Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria[1] and male infertility.[3]
References
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External links
[edit | edit source]- Human ADCY10 genome location and ADCY10 gene details page in the UCSC Genome Browser.
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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