ABCC12
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.[1][2][3]
Function
[edit | edit source]This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.[3] Loss of function is implicated in hereditary cholestasis.
References
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External links
[edit | edit source]- Human ABCC12 genome location and ABCC12 gene details page in the UCSC Genome Browser.
Adding link to ABCC12 gene details page and display in UCSC genome browser.
Further reading
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