A1CF
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene.[1][2][3]
Gene
[edit | edit source]Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.[3]
Function
[edit | edit source]Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC1 and a complementation factor encoded by this gene.[4] The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.[3]
Its deletion results in lethality in mice.[5]
Interactions
[edit | edit source]A1CF has been shown to interact with APOBEC1,[6][7] CUGBP2,[8] and SYNCRIP.[9][6]
References
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External links
[edit | edit source]- Human A1CF genome location and A1CF gene details page in the UCSC Genome Browser.
Further reading
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