Xg antigen system
(Redirected from XG antigen system)
| Xg blood group | |
|---|---|
| File:Serology interpretation of antibody panel for blood group antigens.jpg Interpretation of antibody panel to detect patient antibodies towards the most relevant human blood group systems, including Xg. | |
| Identifiers | |
| Symbol | XG |
| Alt. symbols | PBDX |
| NCBI gene | 7499 |
| HGNC | 12806 |
| RefSeq | NM_175569 |
| Other data | |
| Locus | Chr. X p22.32 |
The XG antigen is a red blood cell surface antigen discovered in 1962[1] by researchers at the MRC Blood Group Unit.[2]
The PBDX gene that encodes the antigen is located on the short arm of the X chromosome.[3][4] Since males normally have one X chromosome they are considered hemizygotes. Since women have two copies of the gene and could be heterozygotic for the presence or absence of the functioning gene they could (through the process of lyonisation) express the functioning protein on just some of their red blood cells.[citation needed]
Frequency
[edit | edit source]| Population frequencies of Xa[5] | ||||||
|---|---|---|---|---|---|---|
| Population | Sample N |
Xg % | ||||
| Australian Aborigines | 352 | 79 | ||||
| Chinese, mainland | 171 | 60 | ||||
| North Europeans | 5,388 | 66 | ||||
| Indians, Bombay | 100 | 65 | ||||
| Israelis | 201 | 66 | ||||
| American Indians | 308 | 77 | ||||
| New-Guineans | 263 | 85 | ||||
| New York's Afro-Americans | 219 | 55 | ||||
| Sardinians | 322 | 76 | ||||
| Taiwan Chinese | 178 | 53 | ||||
| Taiwan Aborigines | 164 | 38 | ||||
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Mann, J. D., Cahan, A., Gelb, A. G., Fisher, N., Hamper, J., Tippett, P., Sanger, R., Race, R. R A sex-linked blood group. Lancet. 1962;279:8.
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Harrison et al. (1977): Human biology – An introduction to human evolution, variation, growth and ecology. Oxford University Press, Oxford, Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)..
