UDP-glucose 6-dehydrogenase
(Redirected from UGDH)
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UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.[1][2][3]
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.[3]
This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.
Loss of UGDH has recently been implicated in epileptic encephalopathy in humans[4]
Nomenclature
[edit | edit source]This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is UDP-glucose:NAD+ 6-oxidoreductase.
Other names in common use include:
- UDP-glucose dehydrogenase,
- uridine diphosphoglucose dehydrogenase,
- UDPG dehydrogenase,
- UDPG:NAD oxidoreductase,
- UDP-alpha-D-glucose:NAD oxidoreductase,
- UDP-glucose:NAD+ oxidoreductase,
- uridine diphosphate glucose dehydrogenase,
- UDP-D-glucose dehydrogenase, and
- uridine diphosphate D-glucose dehydrogenase.
Biochemistry
[edit | edit source]| UDP-glucose 6-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.22 | ||||||||
| CAS no. | 9028-26-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a UDP-glucose 6-dehydrogenase (EC 1.1.1.22) is an enzyme that catalyzes the chemical reaction
+ 2 NAD+
H2O
2 H+
H2O
2 H+
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+ 2 NADH
The 3 substrates of this enzyme are UDP-glucose, oxidised nicotinamide adenine dinucleotide (NAD+), and water. Its products are UDP-glucuronic acid, reduced NADH, and two protons.[5]
References
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- ^ Hengel, H., Bosso-Lefèvre, C., Grady, G. et al. Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. Nat Commun 11, 595 (2020). https://doi.org/10.1038/s41467-020-14360-7
- ^ Enzyme 1.1.1.22 at KEGG Pathway Database.
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Further reading
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