Trypanocidal agent
(Redirected from Trypanocide)
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites.[1]
Examples include:[2]
- Aminoquinuride[3]
- benzonidazole
- blasticidin S
- DAPI
- diminazene
- diminazene aceturate
- eflornithine
- ethidium
- isometamidium chloride
- lonidamine
- melaminylthioarsenate
- melarsoprol
- nifurtimox
- pentamidine
- posaconazole
- puromycin
- quinapyramine
- salicylhydroxamic acid
- suramin
- tetraphenylporphine sulfonate
Resistance
[edit | edit source]As of 2008[update], 17[4] or 18[5] African countries had confirmed resistant parasite populations, and as of 2011[update] that was up to 21.[5] Multiply resistant populations are an increasing problem in the Adamawa Region of Cameroon[6] and south east Mali.[7] The Gibe River Valley in southwest Ethiopia showed universal resistance (in T. congolense isolated from Boran cattle) between July 1989 and February 1993.[8] This likely indicates a permanent loss of function in this area for the tested trypanocides, diminazene aceturate, isometamidium chloride, and homidium chloride.[8]
See also
[edit | edit source]References
[edit | edit source]- ^ Trypanocidal+Agents at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ MeSH list of agents 82014344
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