Testis-expressed protein 14
Lua error in Module:Infobox_gene at line 58: attempt to index field 'wikibase' (a nil value). Testis-expressed protein 14 is a protein in humans encoded by the TEX14 gene, and is 1497 amino acids in length.[1] TEX14 plays a vital role in the formation of germ cells, as it is an essential component of the mammalian germ cell interphase bridge.[2]
An orthologue of TEX14 exists in other mammals, also called TEX14.
Function
[edit | edit source]During cell division, specifically in telophase, the spindle is converted into a midbody. This midbody contains a ring of TEX14, which gradually travels outwards as cell division progresses. Finally, TEX14 marks the ends of the intercellular bridge.[3]
Clinical significance
[edit | edit source]Male mice and male pigs that lack normal TEX14 are incapable of producing functional sperm, and thus are infertile.[2][4] However, TEX14-knockout female mice are not infertile.[5]
References
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