ELOB

Elongin B is a protein that in humans is encoded by the ELOB gene.

Function

Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

TCEB2 has been shown to interact with:

• CUL2,
• TCEB1, and
• Von Hippel-Lindau tumor suppressor.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Elongin-B