STX1A

Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.^[1]

Function

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process.

Syntaxin-1A is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.^[2]

Clinical significance

Syntaxins serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis.^[3]

The expression level of STX1A is directly correlated with intelligence in Williams syndrome.^[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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Nicotine Activity on Dopaminergic Neurons edit

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Interactions

STX1A has been shown to interact with:

CPLX1,^[5]^[6]^[7]
CFTR,^[8]^[9]
NAPA,^[10]^[11]
RNF40,^[12]
SCNN1G,^[13]
SLC6A1,^[14]^[15]^[16]
SNAP-25,^[5]^[6]^[10]^[17]^[18]^[19]^[20]^[21]^[22]^[23]^[24]
SNAP23,^[22]^[24]^[25]^[26]^[27]
STXBP1,^[5]^[10]^[18]^[28]^[29]
STXBP5,^[30]^[31]
SYT1^[32]^[33]
UNC13B,^[34]
VAMP2,^[5]^[6]^[10]^[29]^[35]^[36] and
VAMP8.^[37]

References

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External links

Overview of all the structural information available in the PDB for UniProt: P32851 (Rat Syntaxin-1A) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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STX1A

Contents

Function

Clinical significance

Interactive pathway map

Interactions

See also

References

Further reading

External links

Navigation menu

STX1A

Function

Clinical significance

Interactive pathway map

Interactions

See also

References

Further reading

External links

Navigation menu

Search