SRA1

For the flying boat fighter aircraft, see Saunders-Roe SR.A/1.

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.

Function

This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.

Interactions

SRA1 has been shown to interact with:

• Estrogen receptor alpha,
• DDX17,
• Nuclear receptor coactivator 2, and
• SPEN.

The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA. Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.

External links

• SRA1 human gene location in the UCSC Genome Browser.
• SRA1 human gene details in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9HD15 (Human Steroid receptor RNA activator 1) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q80VJ2 (Mouse Steroid receptor RNA activator 1) at the PDBe-KB.