POLR2A
(Redirected from RPB1)
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.
Function
[edit | edit source]This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.[1]
Interactions
[edit | edit source]POLR2A has been shown to interact with:
- BRCA1,[2][3][4][5]
- CREBBP,[6]
- CTDP1,[3]
- CDK8,[6]
- GTF2B,[3]
- GTF2F1,[3][6]
- GTF2H4,[3]
- MED21,[3][6][7]
- MED26,[8]
- PCAF,[6]
- POLR2C,[9]
- POLR2E,[9]
- POLR2H,[9]
- POLR2L,[9]
- PQBP1,[10]
- SMARCA2,[6][11][12]
- SMARCA4[11][12][13]
- SMARCB1,[6][11][12]
- SMYD3,[14]
- SND1,[15]
- SUPT5H,[16][17]
- TAF11,[3]
- TBP,[3]
- TCEA1,[18][19][20]
- TCERG1,[21] and
- ZNF74.[22]
References
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Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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