Repression of heat shock gene expression (ROSE) element

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Repression of heat shock gene expression (ROSE) element
File:RF00435.jpg
Predicted secondary structure and sequence conservation of ROSE
Identifiers
SymbolROSE
RfamRF00435
Other data
RNA typeCis-reg; thermoregulator
DomainBacteria
SOSO:0000204
PDB structuresPDBe
File:PDB 2gio EBI.png
A representation of the 3D structure of the microROSE RNA. This derived from a solution NMR structure of the microROSE element.[1]

The repression of heat shock gene expression (ROSE) element is an RNA element found in the 5' UTR of some heat shock protein's mRNAs. The ROSE element is an RNA thermometer that negatively regulates heat shock gene expression. The secondary structure is thought to be altered by temperature, thus it is an RNA thermometer. This structure blocks access to the ribosome binding site at normal temperatures. During heat shock however, the structure changes freeing the ribosome binding site and allowing expression to occur.[2][3]

A partial structure of this RNA element has been determined using NMR.[1]

ROSE1 and ROSEAT2

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ROSE1 and ROSEAT2 are specific examples of ROSE elements.[4] ROSE1 is found in Bradyrhizobium japonicum whereas ROSEAT2 is a closely related element from Agrobacterium tumefaciens. The two RNA elements have similar secondary structures with ROSE1 having an extra hairpin.[4] All ROSE elements contain a characteristic 'bulged G' opposite the Shine-Dalgarno sequence binding site, without this nucleotide the RNA thermometer loses its temperature-sensitivity.[5]

IpbA

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Expression of the heat shock protein IpbA in species of Pseudomonas is controlled by a ROSE-type RNA thermometer. This thermometer only consists of two hairpins. It inhibits translation of IpbA at low temperatures and permits translation when temperature increases.[6]

rhlA and lsdI ROSE-like elements

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Pseudomonas aeruginosa quorum sensing-dependent virulence factors can be thermoregulated. ROSE thermometer present in the 5'UTR of rhlA and ROSE-like thermometer in the 5'UTR of lasI block the translation at lower temperatures.[7]

See also

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References

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  2. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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  4. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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Further reading

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  • Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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