Rhomboid-related protein 2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene.[1]
Function
[edit | edit source]The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid-1. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases.
RHBDL2 functions as a sheddase and is localized to the plasma membrane.[2] Known substrates of RHBDL2 include thrombomodulin and epidermal growth factor;[2] profiling of the substrate repertoire of RHBDL2 has identified a number of additional type I membrane proteins substrates, including BCAM, SPINT1, and CLCP1.[3]
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
