Repulsive guidance molecule B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family.[1] In humans this protein is encoded by the RGMB gene.[2]
Function
[edit | edit source]RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system.[3][4]
There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling.[5][6] Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.[7]
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.