Dornase alfa
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| Clinical data | |
|---|---|
| Trade names | Pulmozyme |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a694002 |
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| Routes of administration | Inhalation |
| ATC code | |
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| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
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| UNII | |
| KEGG | |
| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C1321H1999N339O396S9 |
| Molar mass | 29254.04 g·mol−1 |
| ☒check (what is this?) (verify) | |
Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[3] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[3] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[3] It is produced in Chinese hamster ovary cells.[3]
Medical uses
[edit | edit source]Dornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function.[3]
Society and culture
[edit | edit source]Legal status
[edit | edit source]Dornase alfa is an orphan drug.[4]
Research
[edit | edit source]Dornase alfa has been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis.[5][6]
References
[edit | edit source]- ^ a b Product guildlink.com.au
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