Cytosol nonspecific dipeptidase
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| Cytosol nonspecific dipeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.13.18 | ||||||||
| CAS no. | 9025-31-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[1][2][3] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.[4] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".[5] A similar pathway conjugates amino acids to Beta-hydroxybutyric acid.[6]
See also
[edit | edit source]- N-lactoyl-phenylalanine, a chemical compound produced by this enzyme
References
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External links
[edit | edit source]- Cytosol+non-specific+dipeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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