Perisinusoidal space
| Perisinusoidal space | |
|---|---|
 | |
| File:Hepatic structure2.svg Basic liver structure | |
| Details | |
| Location | Liver |
| Identifiers | |
| Latin | spatium perisinusoideum |
| TA98 | Lua error in Module:Wikidata at line 746: attempt to index field 'wikibase' (a nil value). |
| TH | {{#property:P1694}} |
| TE | {{#property:P1693}} |
| FMA | {{#property:P1402}} |
| Anatomical terms of microanatomy [[[d:Lua error in Module:Wikidata at line 865: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]] | |
The perisinusoidal space (or space of Disse) is a space between a hepatocyte, and a sinusoid in the liver. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the sinusoid endothelium facilitates this transport.[1] The perisinusoidal space also contains hepatic stellate cells (also known as Ito cells or lipocytes), which store vitamin A in characteristic lipid droplets.[2]
This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes such as bilirubin.
The Space of Disse is named for the German anatomist Joseph Disse (1852–1912).[3]
Pathophysiology
[edit | edit source]Fibrosis
[edit | edit source]Liver injury from a number of causes can activate the hepatic stellate cells into transdifferentiated and prolific myofibroblasts.[4] The myofibroblasts synthesize and secrete components of the extracellular matrix including collagen into the perisinusoidal space.[4] This in turn promotes the development of fibrosis, and continuing fibrosis is thought to be responsible for the development of cirrhosis, and liver cancer.[5]
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- UIUC Histology Subject 1317
- Histology image: 22103loa – Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
- Histology image: 15204loa – Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
- Anatomy photo: digestive/mammal/liver5/liver7 - Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)"
Lua error in Module:Authority_control at line 153: attempt to index field 'wikibase' (a nil value).