PLCB4
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.[2]
Oncogenic mutations in this gene have been found in cases of uveal melanoma.[3]
References
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Further reading
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