Neutrophil cytosolic factor 1
(Redirected from P47phox)
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene.[1]
Function
[edit | edit source]The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.[1]
Genetic variability in the NCF1 gene has been found to be related to a higher chance of getting autoimmune diseases such as Sjögren's syndrome, rheumatoid arthritis and lupus erythematosus.[2]
p47 is vital to the activation of NADPH oxidase. P47 becomes heavily phosphorylated
[edit | edit source]Interactions
[edit | edit source]Neutrophil cytosolic factor 1 has been shown to interact with:
References
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Further reading
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