Nucleoporin 43
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.[1][2]
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004).[supplied by OMIM][2] Along with other nucleoporins.
Structure
[edit | edit source]It folds into a canonical WD40 repeat domain.[3][4]
Disease association
[edit | edit source]High expression of NUP43 in breast cancer is associated with poor overall survival.[5] In chronic myelogenous leukemia (CML), reduction of miRNA-409-5p increases the expression of NUP43 that in turn enhances proliferative potential, cell cycle progression, and imatinib resistance.[6]
Some Nup43 variants have been characterized as causal for the onset of cardiovascular disease (CVD),[7] while Nup43 expression has been associated with attention deficit hyperactivity disorder.[8]
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: Q8NFH3 (Human Nucleoporin Nup43) at the PDBe-KB.
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