Glycylpeptide N-tetradecanoyltransferase 2
| Human N-myristoyltransferase 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:4c2x Human N-myristoyltransferase isoform 2 NMT2.png Human N-myristoyltransferase isoform 2 (NMT2) (based on PDB: 4c2x) | |||||||||
| Identifiers | |||||||||
| Symbol | NMT2 | ||||||||
| Pfam | PF01233 | ||||||||
| InterPro | IPR022676 | ||||||||
| |||||||||
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Glycylpeptide N-tetradecanoyltransferase 2 known also as N-myristoyltransferase, is an enzyme (EC: 2.3.1.97) that in humans is encoded by the NMT2 gene.[1]
Function
[edit | edit source]N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The 496-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.[2]
Interactions
[edit | edit source]NMT2 has been shown to interact with:
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)
