Nuclear receptor co-repressor 1
(Redirected from N-CoR)
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.[1][2]
NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.[1][3]
Loss of function of this protein significantly increases the strength and power of mouse muscles.[4]
Family
[edit | edit source]It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.[5]
Interactions
[edit | edit source]Nuclear receptor co-repressor 1 has been shown to interact with:
- Androgen receptor,[6][7][8][9]
- CHD1,[10]
- Calcitriol receptor[11][12]
- GPS2,[13][14][15]
- Glucocorticoid receptor,[16][17]
- HDAC3,[13][14][15][18][19][20][21]
- HDAC4,[20][22]
- HDAC7A,[18]
- HDAC9,[23]
- HEY2,[24]
- Histone deacetylase 5,[13][22]
- MAP3K7IP2,[25]
- MECP2,[26]
- Peroxisome proliferator-activated receptor alpha,[27]
- Peroxisome proliferator-activated receptor gamma
- Promyelocytic leukemia protein,[28]
- RUNX1T1,[29][30]
- Retinoic acid receptor alpha,[27][31]
- Retinoic acid receptor gamma,[27]
- SAP30,[21][32]
- TBL1XR1,[13][14][15]
- TBL1X,[13][15][19][33] and
- ZBTB33.[14]
Further reading
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References
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- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
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External links
[edit | edit source]- nuclear receptor corepressor 1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C97
- Overview of all the structural information available in the PDB for UniProt: O75376 (Nuclear receptor corepressor 1) at the PDBe-KB.