Metanephrogenic blastema
| Metanephrogenic blastema | |
|---|---|
| Details | |
| Carnegie stage | 14 |
| Days | 35 |
| Precursor | Wolffian duct |
| Gives rise to | Nephron (Bowman's capsule, connecting tubule, distal convoluted tubule, glomerulus, loop of Henle, proximal convoluted tubule), but not collecting duct |
| Identifiers | |
| Latin | blastema metanephrogenicum |
| TA98 | Lua error in Module:Wikidata at line 746: attempt to index field 'wikibase' (a nil value). |
| TH | {{#property:P1694}} |
| TE | {{#property:P1693}} |
| FMA | {{#property:P1402}} |
| Anatomical terminology [[[d:Lua error in Module:Wikidata at line 865: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]] | |
The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud.
The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, glial cell-derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the RET receptor on the ureteric bud,[1] which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, whose product regulates GDNF expression in the developing kidney,[2] lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome).
See also
[edit | edit source]References
[edit | edit source]External links
[edit | edit source]- Swiss embryology (from UL, UB, and UF) turinary/urinhaute01
- genital-017a—Embryo Images at University of North Carolina
- Diagram at mcgill.ca 1
- Diagram at mcgill.ca 2
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