List of breast cancer cell lines

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Template:SHORTDESC: Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer research.[Notes 1]

List of cell lines

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Cell line Primary tumor Origin of cells Estrogen receptors Progesterone receptors ERBB2 amplification Mutated TP53[Notes 2] Tumorigenic in mice Metastasis potential Reference External links
600MPE Invasive ductal carcinoma + – – [3] Cellosaurus
AMJ13 Invasive ductal carcinoma Primary Yes Yes No - - [4] Cellosaurus
AU565 Adenocarcinoma – – + – [3] Cellosaurus
BT-20 Invasive ductal carcinoma Primary No No No Yes Yes [5] Cellosaurus
BT-474 Invasive ductal carcinoma Primary Yes Yes Yes Yes Yes [6] Cellosaurus
BT-483 Invasive ductal carcinoma + + – [3] Cellosaurus
BT-549 Invasive ductal carcinoma – – + [3] Cellosaurus
Evsa-T Invasive ductal carcinoma, mucin-producing, signet-ring type Metastasis (ascites) No Yes ? Yes ? [7] Cellosaurus
HCC 1137 [8]
HCC 1954 [8]
HCC 38 [8]
Hs578T Invasive ductal carcinoma Primary No No No Yes No [9] Cellosaurus
HTB-26 [10]
MCF-7 Invasive ductal carcinoma Metastasis (pleural effusion) Yes Yes[11] No No (wild-type) Yes (with estrogen supplementation) [12] Cellosaurus
MDA-MB-231 Adenocarcinoma Metastasis (pleural effusion) No No No Yes Yes [13] Cellosaurus
SkBr3 Invasive ductal carcinoma Metastasis (pleural effusion) No No Yes Yes No [14] Cellosaurus
T-47D Invasive ductal carcinoma Metastasis (pleural effusion) Yes Yes No Yes Yes (with estrogen supplementation) [15] Cellosaurus
UACC-3199 [16]
ZR-75-1 Invasive ductal carcinoma [17] Cellosaurus

Notes

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  1. ^ The original list was mainly based on the work of Lacroix and Leclercq (2004).[1]
  2. ^ For more data on the nature of TP53 mutations in breast cancer cell lines, see Lacroix et al. (2006).[2]

References

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