Benazepril
| File:Benazepril structure.svg | |
| File:Benazepril-3D-balls.png | |
| Clinical data | |
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| Pronunciation | /bəˈnæzəprɪl/ |
| Trade names | Lotensin, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a692011 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Protein binding | 96.7% |
| Metabolism | Liver glucuronidation |
| Elimination half-life | 10-11 hours |
| Excretion | Kidney and bile duct |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C24H28N2O5 |
| Molar mass | 424.497 g·mol−1 |
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Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[2] It is a reasonable initial treatment for high blood pressure.[2] It is taken by mouth.[2] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.[2]
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.[2] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.[2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.[3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[2]
Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication.[2] In 2023, it was the 172nd most commonly prescribed medication in the United States, with more than 2 million prescriptions.[4][5]
Medical uses
[edit | edit source]Lotensin is indicated for the treatment of hypertension, to lower blood pressure.[1][2]
Side effects
[edit | edit source]The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated.[6]
Contraindications
[edit | edit source]Benazepril can harm the fetus.[7]
Dosage forms
[edit | edit source]It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).
Veterinary uses
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Under the brand names Fortekor (Novartis)[8] and VetACE (Jurox Animal Health),[9] benazepril is used to treat congestive heart failure in dogs[10][11] and chronic kidney failure in cats and dogs.[12]
References
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