Link domain
| Link domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:PDB 1poz EBI.jpg Structure of the hyaluronan-binding domain of human CD44 | |||||||||
| Identifiers | |||||||||
| Symbol | LINK | ||||||||
| Pfam | PF00193 | ||||||||
| Pfam clan | CL0056 | ||||||||
| InterPro | IPR000538 | ||||||||
| SMART | SM00445 | ||||||||
| PROSITE | PDOC00955 | ||||||||
| SCOP2 | 1o7b / SCOPe / SUPFAM | ||||||||
| CDD | cd01102 | ||||||||
| |||||||||
A Link domain or Link module, also known as Xlink domain (X for extracellular), is a protein domain that binds to hyaluronic acid.[1] It is important in blood cell migration and apoptosis.[2] The link domain is found in some extracellular proteins in vertebrates such as the hyalectans.[3] It appears to be involved in extracellular matrix assembly and stability, cell adhesion, and migration.[3][4]
Structure
[edit | edit source]The structure has been shown to consist of two alpha helices and two antiparallel beta sheets arranged around a large hydrophobic core similar to that of C-type lectin.[5] This domain contains four conserved cysteines involved in two disulphide bonds. The link domain has also been termed HABM (hyaluronic acid binding module)[4] and PTR (proteoglycan tandem repeat).[6]
Link domain proteins
[edit | edit source]Proteins which contain the link domain include:
- the hyalectans (a family of proteoglycans): aggrecan, brevican, neurocan and versican, which are expressed in the CNS;
- the cartilage link protein (LP), a proteoglycan that together with HA and aggrecan forms multimolecular aggregates;
- Tumour necrosis factor-inducible protein 6 (TSG-6), which may be involved in cell-cell and cell-matrix interactions during inflammation and tumourigenesis;
- CD44 antigen, the main cell surface receptor for HA.
See also
[edit | edit source]References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).