Latent TGF-beta binding protein

The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

latent transforming growth factor beta binding protein 1
Identifiers
Symbol	LTBP1
Alt. symbols	TGF-beta1-BP-1
NCBI gene	4052
HGNC	6714
OMIM	150390
RefSeq	NM_206943
UniProt	Q14766
Other data
Locus	Chr. 2 p22-p21
Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 2
Identifiers
Symbol	LTBP2
Alt. symbols	LTBP3, C14orf141
NCBI gene	4053
HGNC	6715
OMIM	602091
RefSeq	NM_000428
UniProt	Q14767
Other data
Locus	Chr. 14 q24.3
Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 3
Identifiers
Symbol	LTBP3
Alt. symbols	LTBP2
NCBI gene	4054
HGNC	6716
OMIM	602090
RefSeq	NM_021070
UniProt	Q9NS15
Other data
Locus	Chr. 11 q12
Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 4
Identifiers
Symbol	LTBP4
Alt. symbols	LTBP-4, LTBP-4L
NCBI gene	8425
HGNC	6717
OMIM	604710
RefSeq	NM_003573
UniProt	Q8N2S1
Other data
Locus	Chr. 19 q13.1-13.2
Search for Structures Swiss-model Domains InterPro

External links

• Latent+TGF-beta+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Latent-transforming growth factor beta-binding protein 1