Lamin B1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.[1][2][3]
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.[3] Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.
Interactions
[edit | edit source]LMNB1 has been shown to interact with Thymopoietin.[4][5] When double-strand breaks are induced in DNA by ionizing radiation, lamin B1 promotes repair of the breaks, as well as cell survival, by maintaining the level of the RAD51 protein that is employed in homologous recombinational repair.[6]
Pathology
[edit | edit source]Mutations affecting the LMNB1 gene cause autosomal dominant adult-onset demyelinating leukodystrophy.
See also
[edit | edit source]References
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- ^ Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage. FASEB J. 2015 Jun;29(6):2514-25. doi: 10.1096/fj.14-265546. Epub 2015 Mar 2. PMID 25733566
Further reading
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