Importin subunit alpha-3
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Importin subunit alpha-3, also known as karyopherin subunit alpha-4, is a protein that in humans is encoded by the KPNA4 gene.[1][2]
Function
[edit | edit source]The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.[3]
Interactions
[edit | edit source]KPNA4 has been shown to interact with RECQL[1] and STAT3.[4]
References
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Further reading
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