KAT8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). K(lysine) acetyltransferase 8 (KAT8) is an enzyme that in humans is encoded by the KAT8 gene.[1][2]
Function
[edit | edit source]The MYST family of histone acetyltransferases, which includes KAT8, was named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.[2]
KAT8 is also known as MOF, and in humans hMOF. Given its fundamental role in modulating higher-order chromatin structure, hMOF is involved in many of the steps of the DNA damage response.[3] The human hMOF gene encodes an enzyme that specifically acetylates histone H4 at lysine 16.[3][4] The depletion of hMOF greatly decreases DNA double-strand break repair by both non-homologous end joining and homologous recombination.[4] Thus MOF activity is critical for double-strand break repair.[4]
Interactions
[edit | edit source]KAT8 has been shown to interact with MORF4L1.[5]
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: Q9H7Z6 (Human Histone acetyltransferase KAT8) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q9D1P2 (Mouse Histone acetyltransferase KAT8) at the PDBe-KB.
