Helicase–primase complex
(Redirected from Helicase-primase complex)
A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.[1]
The complex is used by herpesviruses, in which it is responsible for lytic DNA virus replication.[2][3][4] In many dsDNA viruses, primase and helicase are fused into a single polypeptide chain, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively.[5] A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.
List of H-P by virus name
[edit | edit source]List of H-P inhibitors
[edit | edit source]- Amenamevir (ASP2151)[6]
- Pritelivir (BAY 57–1293, AIC316)
- BILS 22 BS[6]
- T157602[6]
References
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