DEFA6
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene.[1][2] DEFA6 is expressed in the Paneth cells of the ileum.[3]
Function
[edit | edit source]The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 has poor antibacterial potency.[4] However, HD6 affords protection against invasion by enteric bacterial pathogens by self-assembly to form fibrils and nanonets that surround and entangle bacteria.[5]
Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.[1]
References
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Further reading
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External links
[edit | edit source]- PDBe-KB provides an overview of all the structure information available in the PDB for Human Defensin-6
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