Grb2 associated binding protein 3
(Redirected from GAB3)
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GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. [1]
Function
[edit | edit source]This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
