Fringe gene
(Redirected from Fringe Genes)
| Fringe | |
|---|---|
| Identifiers | |
| Symbol | FNG |
| InterPro | IPR017374 |
| Membranome | 1299 |
Fringe genes are important in the workings of the notch signaling pathway.[1]
In Drosophila melanogaster (the fruit fly) the fringe gene (fng) was identified as part of the notch mechanism by Dr. Kenneth Irvine at the Waksman Institute at Rutgers.[citation needed] Later based on similarity, the manic fringe (MFNG), the radical fringe (RFNG) and lunatic fringe (LFNG)[2][3] genes were identified in mammals.
Fringe genes encode O-fucose specific β-1,3-N-Acetylglucosaminyltransferases (GlcNAcT) glycosyltransferases.
The gene products of radical fringe stimulate the Apical Ectodermal Ridge in limb-bud formation.
The mouse and human Fringe family members map to three different chromosomes:
- Mfng maps to mouse Chr 15 and to human Chr 22.
- Lfng maps to mouse Chr 5 and human Chr 7.
- Rfng maps to mouse Chr 11 and human Chr 17.
References
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