File:Notch lateral effects.png
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Summary
| Description |
English: Schematic representation of the Notch signaling pathway and the processes of lateral inhibition and induction.
A sending cell presenting a Dll or Jag ligand interacts with the receiver cell Notch receptor. After consecutive cleavages the Notch intracellular domain (NICD) translocates to the nucleus where it modulates the transcription of target genes. (A) In lateral inhibition the signaling cells induces Notch signaling in the receiving cell, upon which the receiving cell downregulates its Notch ligands. The cell fate difference between the two cells becomes more pronounced. This process contributes to tissue patterning. (B) In lateral induction the signal-receiving cells upregulate ligands and can thus function as both a sending and a receiving cell, propagating the signal through layers of cells. This process contributes to tissue homeostasis
Nederlands: Schematische weergave van Notch-signalering en de processen van laterale inhibitie en laterale inductie. De zendercel (bovenin; rose) presenteert een ligand (DII of Jag) en interageert met de Notch-receptor van de ontvangercel (onderin; lichtoranje). Deze wordt net boven het membraan in het Notch intracellulaire domein (NICD) door enzymen geklieft. Het intracellulaire gedeelte associeert zich met het DNA in de nucleus om daar de transcriptie van de bestemde genen te moduleren. (A) De ontvangercel (lichtoranje) ontvangt een inhiberend signaal van een naburige zendercel (rose). Dit betekent dat de notch-liganden aan het celoppervlak van de ontvangercel verminderen of verdwijnen en deze cel dus niet meer kan zenden. Het signaal breidt zich niet verder uit. Deze vorm van laterale signalering is belangrijk in patroonvorming. (B) Bij laterale inductie reguleren de cellen die het signaal ontvangen de upregulatie van de ligand bij de eigen en naburige cellen en deze kunnen dus zowel verzenden als ontvangen, waarbij het signaal door cellagen wordt verspreid. Dit proces draagt bij aan de homeostase van weefsels. |
| Date | |
| Source |
Laura A. Tiemeijer, Sami Sanlidag, Carlijn V.C. Bouten, Cecilia M. Sahlgren, Engineering tissue morphogenesis: taking it up a Notch, Trends in Biotechnology, Volume 40, Issue 8, 2022, Pages 945-957, ISSN 0167-7799, https://doi.org/10.1016/j.tibtech.2022.01.007 |
| Author | Laura A. Tiemeijer |
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| current | 15:31, 6 December 2024 | | 2,732 × 1,806 (2.25 MB) | wikimediacommons>Phacelias | Uploaded a work by Laura A. Tiemeijer from Laura A. Tiemeijer, Sami Sanlidag, Carlijn V.C. Bouten, Cecilia M. Sahlgren, Engineering tissue morphogenesis: taking it up a Notch, Trends in Biotechnology, Volume 40, Issue 8, 2022, Pages 945-957, ISSN 0167-7799, https://doi.org/10.1016/j.tibtech.2022.01.007 with UploadWizard |
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