English: (A) Domain architecture of the protomers forming the BBSome core complex. The parts of the primary structure that could be assigned in the density is shown in full colors, while non-modeled regions are represented in opaque colors. (B) Composite cryo-EM density map of the BBSome core complex in different orientations. Each protomer is colored differently and the thresholds of the segmented densities of the individual domains were adjusted to visualize each domain at an optimal signal intensity. BBS5 is poorly visible at the signal level of the other subunits and required a reconstruction from a subset of particles, which was obtained by 3D-sorting. (C) The final model of the core BBSome. (D): Schematic representation of the complex, highlighting the two β-propeller domains of BBS1 and BBS9 as red and green segmented wheels, and the super helical arrangements of the TPR repeats of BBS4 and BBS8 as blue and cyan helices.