Muscle fascicle

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Muscle fascicle
File:Skeletal muscle svg hariadhi.svg
Structure of a skeletal muscle. (Fascicle labeled at bottom right.)
Details
Part ofSkeletal muscle
Identifiers
Latinfasiculus muscularis
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Anatomical terminology
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A muscle fascicle is a bundle of skeletal muscle fibers surrounded by perimysium, a type of connective tissue.[1]

Structure

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Muscle cells are grouped into muscle fascicles by enveloping perimysium connective tissue.[1] Fascicles are bundled together by epimysium connective tissue.[1] Muscle fascicles typically only contain one type of muscle cell (either type I fibres or type II fibres), but can contain a mixture of both types.[2]

Function

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In the heart, specialized cardiac muscle cells transmit electrical impulses from the atrioventricular node (AV node) to the Purkinje fibers – fascicles, also referred to as bundle branches.[citation needed] These start as a single fascicle of fibers at the AV node called the bundle of His that then splits into three bundle branches: the right fascicular branch, left anterior fascicular branch, and left posterior fascicular branch.

Clinical significance

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Myositis may cause thickening of the muscle fascicles.[3] This may be detected with ultrasound scans.[3]

Muscle fascicle structure is a useful diagnostic tool for dermatomyositis. Myocytes towards the edges of the muscle fascicle are typically narrower, while those at the centre of the muscle fascicle are a normal thickness.[4]

Muscle fascicles may be involved in myokymia, although commonly only individual myocytes are involved.[5]

See also

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References

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