Epimerase and racemase
Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules.[1] Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry. Epimerases catalyze the stereochemical inversion of the configuration about an asymmetric carbon atom in a substrate having more than one center of asymmetry, thus interconverting epimers.
Human epimerases include methylmalonyl-CoA epimerase, involved in the metabolic breakdown of the amino acids alanine, isoleucine, methionine and valine,[2] and UDP-glucose 4-epimerase, which is used in the final step of galactose metabolism - catalyzing the reversible conversion of UDP-galactose to UDP-glucose.
See also
[edit | edit source]References
[edit | edit source]External links
[edit | edit source]- http://medical-dictionary.thefreedictionary.com/racemase
- http://medical-dictionary.thefreedictionary.com/epimerase
- Entry+Term+Epimerases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
