Enolase 2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[1][2] Gamma-enolase is a phosphopyruvate hydratase.
Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[1]
Interactive pathway map
[edit | edit source]Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
Utility
[edit | edit source]Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.[3]
References
[edit | edit source]- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Online Mendelian Inheritance in Man (OMIM): Enolase 2 - 131360
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: P09104 (Human Gamma-enolase) at the PDBe-KB.
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