Dimethylmalate dehydrogenase
Jump to navigation
Jump to search
| dimethylmalate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.84 | ||||||||
| CAS no. | 37250-21-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, dimethylmalate dehydrogenase (EC 1.1.1.84) is an enzyme that catalyzes the chemical reaction
[[File:No image file is associated with Q27098124 via Wikidata. Try a qualifier ID or use chemrxn/subunit.|frameless|class=skin-invert-image|alt=2D representation of the chemical structure of Q27098124.]]
+ NAD+
H+
H+
[[File:No image file is associated with Q2823217 via Wikidata. Try a qualifier ID or use chemrxn/subunit.|frameless|class=skin-invert-image|alt=2D representation of the chemical structure of Q2823217.]]
+ CO2 + NADH
The two substrates of this enzyme are (R)-3,3-dimethylmalic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are α-ketoisovaleric acid, carbon dioxide, reduced NADH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating). This enzyme is also called beta,beta-dimethylmalate dehydrogenase. This enzyme participates in pantothenate and coa biosynthesis. It has 5 cofactors: ammonia, manganese, cobalt, potassium, and NH4+.
References
[edit | edit source]Lua error in mw.title.lua at line 392: bad argument #2 to 'title.new' (unrecognized namespace name 'Portal').
