Deltex e3 ubiquitin ligase 3
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Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene.[1] It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c.[2] DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.[2]
Function
[edit | edit source]DTX3 functions as an E3 ubiquitin ligase.[3] Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.[2]
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
