Thymidine triphosphate

Thymidine triphosphate

Skeletal formula of thymidine triphosphate, 3- negative charge
Space-filling model of the thymidine triphosphate molecule, 4- negative charge
Names
IUPAC name Thymidine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name O1-{[(2R,3S,5R)-5-(2,4-Dioxo-5-methyl-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Other names dTTP, 2′-Deoxythymidine triphosphate
Identifiers
CAS Number	365-08-2 checkY
3D model (JSmol)	Interactive image
ChEBI	CHEBI:18077
ChEMBL	ChEMBL363559 ☒N
ChemSpider	58493 ☒N=
DrugBank	DB02452
ECHA InfoCard
EC Number	206-669-7
E number
IUPHAR/BPS	5505
KEGG	C00459
MeSH	thymidine+5'-triphosphate
PubChem CID	64968
UNII	QOP4K539MU checkY
CompTox Dashboard (EPA)	{{#property:P3117}}
InChI InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1 Key: NHVNXKFIZYSCEB-XLPZGREQSA-N
SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
Properties
Chemical formula	C10H17N2O14P3
Molar mass	482.168
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒N (what is checkY☒N ?) Infobox references

Thymidine triphosphate (TTP), also called deoxythymidine triphosphate (dTTP), is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleoside triphosphates, thymidine triphosphate does not always contain the "deoxy" prefix in its name. This is because dTTP does not have a corresponding ribonucleoside triphosphate, as the uridine triphosphate, which lacks thymidine's 5-methylation, is used instead.

dTTP is synthesized via the methylation of dUMP via thymidylate synthase.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.